ProMedTours > Treatments > Pruritus

PSC - Primary Sclerosing Cholangitis

The PSC is a chronic inflammation of the bile ducts within (intrahepatic) and / or outside (extrahepatic) the liver without the previous occurrence of acute inflammation or gallstones.

The examination image of the bile ducts of a PSC patient shows the typical narrowing of the bile ducts (stenosis) alternating with baggy extensions. The stenoses are caused by inflammation, the extensions result from the stowage of bile in such stenosis. The stowage of bile in the liver is the reason for further disease symptoms due to the toxic effect of the bile concerning the liver cells. Unfortunately, PSC is still not curable.

Reasons of this disease are still unknown. An early assumption states that an autoimmune disease causes an attack where the body’s own defense system starts to attack other body parts.

In addition, other factors, such as viruses or bacteria in your body are being discussed. It seems likely that the interplay of several factors create the PSC. Consequently, one can do nothing to prevent the disease so far. Therefore, it is important to pay special attention to any symptoms. That is the only way to detect and to treat the disease at an early stage.


Important signs of PSC are:

  • Tiredness
  • Inefficiency
  • Pressure in the right upper abdomen to abdominal pain
  • jaundice (icterus)
  • increased cholestasis idicating enzymes: gamma-GT and AP (Enzymes that show elevated values a bile congestion)
  • increased transferase: GOT and GPT (enzymes that indicate elevated levels of cell damage of the liver)
  • Liver enlargement (hepatomegaly)
  • enlarged spleen (splenomegaly)

Pruritus (itching) is the most common pain in addition to subjective discomfort complained of by patients in the dermatological practice. It occurs with visible and invisible changes in the skin.

You are not alone –thousands of people suffer from an annoying to a painful feeling like you. Please, do not resign even if therapeutic treatments did not relieve the pain and only taking drugs is helpful - possible alternative awaits you in Germany.

Existing alternatives

Although medications relieve your displaying symptoms, they show negative side effects in many cases. Breathe again - possible alternatives may exist in Germany. In Mecklenburg Western Pomerania, Dr. J. Stange invented and introduced a unique method called extracorporeal albumin dialysis which can be successful even in your cases.

Concept of extracorporeal albumin dialysis (ECAD)

ECAD is a blood purification method that derived from kidney dialysis. As in kidney dialysis, blood is pumped from a vein and flows through hollow fiber membranes looking like straws which are surrounded by a cleansing solution. The pores of those hollow fiber membranes are barely large enough to allow small toxic molecules such as urea or ammonia to be washed out of the blood into the dialysis solution, but small enough to prevent the patients’ blood to lose valuable proteins or even blood cells.

During the albumin dialysis the human plasma protein albumin is added to the cleansing solution. It is responsible for binding the toxins and transporting them to the liver. It can act like a natural detergent or soap to rinse the toxins of the patients’ proteins into the cleansing solution.

In albumin dialysis special transport proteins with free binding filter the toxins behind a special membrane from the blood. During treatment, you are directly connected to the albumin circuit through a catheter. The toxins are continuously transported into the dialysate and thus removed from the blood. After the removal of toxins the albumin molecules are cleaned and conducted back to the membrane within the closed circuit, where they can bind toxins from the blood again.

Since the method was developed another surprising effect was discovered: It relieved patients who suffered from pruritus from their itching. In the mean time, several studies have shown that even in otherwise therapy resistant cases of itching due to liver disease, albumin dialysis proved to be effective (Pares et al Am J Gastroenterol 2004).

The average duration of the treatment is five to seven days. During this time, you will be dialyzed 3-5 times, depending on the severity of your case. It can implement ambulatory or also be performed in your hotel room.

80% of the patients respond to two till three daily treatments and have a symptom relieve for up to 3-4 months.

So do not hesitate, send an inquiry on your needed surgery! The decision for such treatment is surely the result of thorough considerations. Your trust is our duty and obligatory. Our team members, the medical team and the nursing staff supports you with expertise, advise and make your stay as pleasant as possible. We are happy to inform you individually and assist you with every detail. Start a better life NOW by sending us your inquiry.